Fig. 1
From: Intermittent energy restriction induces changes in breast gene expression and systemic metabolism

Degree of dietary energy restriction during four to five weeks of intermittent energy restriction (IER) and continuous energy restriction (CER). The IER cohort undertook 65 % energy restriction (ER) on two consecutive days per week and additionally restricted their energy intake to an average of 38 % below their baseline intake on the remaining five days of the week, which was unplanned (blue solid line). The planned and unplanned energy restriction resulted in an overall 45 % energy restriction over the one-month trial period (blue dashed line). For comparison our previous study of CER involved a 60 % daily energy restriction over a one-month period. TP1 time point 1 (baseline): breast gene expression, adipocyte size, serum hormones, urine and serum metabolomics, weight and anthropometry. TP2 time point 2 (immediately after two restricted days): breast gene expression, adipocyte size, serum hormones, urine and serum metabolomics, weight and anthropometry. TP3 time point 3 (after 5 days of normal healthy eating): serum hormones, urine and serum metabolomics, weight and anthropometry