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Fig. 5 | Breast Cancer Research

Fig. 5

From: Cholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor-positive breast cancer

Fig. 5

Enzymes within the cholesterol biosynthesis pathway are associated with poor response on tamoxifen. a On-treatment gene expression of MSMO1, LBR, SQLE and EBP in patients treated with anastrozole. b Association of on-treatment gene expression of MSMO1, LBR, SQLE and EBP and 2-week Ki67 value. Spearman’s rank correlation coefficients (rho) and p values are depicted. c On-treatment gene expression of MSMO1, LBR, SQLE and EBP in patients treated with letrozole. Black, responders; red, non-responders. d Kaplan–Meier plots revealing the association of high or low pre-treatment gene expression of MSMO1, LBR, SQLE and EBP in ER+ BC patients treated with tamoxifen, from publicly available data collected over 10 years. Red, patients with higher gene expression; black, patients with lower gene expression

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