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Fig. 5 | Breast Cancer Research

Fig. 5

From: CD24 cell surface expression in Mvt1 mammary cancer cells serves as a biomarker for sensitivity to anti-IGF1R therapy

Fig. 5

IGF1R-KD enhances CD24+ cancer cells plasticity in vivo. a Experimental strategy scheme is presented. CD24+ control or CD24+ IGF1R-KD cells were injected into the mammary fat pads, after 4 weeks, tumors were harvested and CD24 expression was evaluated. b CD24 expression in GFP-expressing cancer cells from mammary tumors was determined by FACS analysis. c Comparison of CD24+ population between control and IGF1R-KD tumors in WT and MKR mice. Mann-Whitney test was performed to compare between control and IGF1R-KD tumors, *** P < 0.001. FACS fluorescence-activated cell sorting, GFP green fluorescent protein, IGF1R insulin-like growth factor receptor, KD knockdown

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