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Fig. 1 | Breast Cancer Research

Fig. 1

From: CD24 cell surface expression in Mvt1 mammary cancer cells serves as a biomarker for sensitivity to anti-IGF1R therapy

Fig. 1

CD24+ cells demonstrate significantly higher levels of the IGF1R. a Western blot analysis of IGF1R expression in Mvt1 cells infected with control or IGF1R shRNA as indicated. b Protein expression was quantified relative to β-actin expression by densitometric analysis. c Control and IGF1R-KD cells were injected into the fourth mammary fat pad of 8-week-old virgin female FVB/N mice (50,000 cells/mouse) and tumor volume was measured during a 5-week period. d Western blot analysis of IGF1R expression in CD24- and CD24+ Mvt1 cells. e Protein expression was quantified relative to β-actin expression by densitometric analysis. The Mann-Whitney test was performed to compare the difference in IGF1R between CD24+ and CD24+ cells ***P < 0.001. IGF1R insulin-like growth factor receptor, KD knockdown

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