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Table 1 Mean micronuclei yields and G2/M checkpoint efficiency ratios obtained with the G2 micronucleus assay

From: Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation

  Micronucleus yield (MN/1000 BN) G2/M checkpoint efficiency (MNCAF+/MNCAF)
  0 Gy 2 Gy 4 Gy 2 Gy 4 Gy
Healthy volunteers      
 Mean 15 61 91 2 3.1
 SD 10 21 29 0.5 0.8
 SEM 2 5 7 0.1 0.2
BRCA1 mutation carriers      
 Mean 16 83 128 1.6 2.2
 SD 7 31 45 0.5 0.5
 SEM 2 7 10 0.1 0.1
p Value (two-sided t test) 0.83 0.019 0.004 0.01 0.0002
  1. BN binucleated cell, CAF caffeine, MN micronucleus or micronuclei, SD standard deviation