Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation

Breast Cancer Research

Table 1 Mean micronuclei yields and G₂/M checkpoint efficiency ratios obtained with the G₂ micronucleus assay

	Micronucleus yield (MN/1000 BN)			G₂/M checkpoint efficiency (MNCAF⁺/MNCAF⁻)
	0 Gy	2 Gy	4 Gy	2 Gy	4 Gy
Healthy volunteers
Mean	15	61	91	2	3.1
SD	10	21	29	0.5	0.8
SEM	2	5	7	0.1	0.2
BRCA1 mutation carriers
Mean	16	83	128	1.6	2.2
SD	7	31	45	0.5	0.5
SEM	2	7	10	0.1	0.1
p Value (two-sided t test)	0.83	0.019	0.004	0.01	0.0002

BN binucleated cell, CAF caffeine, MN micronucleus or micronuclei, SD standard deviation

ISSN: 1465-542X