From: Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation
Micronucleus yield (MN/1000 BN) | G2/M checkpoint efficiency (MNCAF+/MNCAF−) | ||||
---|---|---|---|---|---|
0 Gy | 2 Gy | 4 Gy | 2 Gy | 4 Gy | |
Healthy volunteers | |||||
Mean | 15 | 61 | 91 | 2 | 3.1 |
SD | 10 | 21 | 29 | 0.5 | 0.8 |
SEM | 2 | 5 | 7 | 0.1 | 0.2 |
BRCA1 mutation carriers | |||||
Mean | 16 | 83 | 128 | 1.6 | 2.2 |
SD | 7 | 31 | 45 | 0.5 | 0.5 |
SEM | 2 | 7 | 10 | 0.1 | 0.1 |
p Value (two-sided t test) | 0.83 | 0.019 | 0.004 | 0.01 | 0.0002 |