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Table 3 Association of background parenchymal uptake with breast cancer by menopausal status

From: Background parenchymal uptake on molecular breast imaging as a breast cancer risk factor: a case-control study

BPU Breast cancer casesa Controlsa OR adjusted for BMIb OR adjusted for BMI and BI-RADS densityb OR adjusted for BMI and postmenopausal HRTb
Overall
 Reader 1
  Photopenic or minimal to mild 40/62 (65) 150/179 (84) 1.0 1.0 1.0
  Moderate or marked 22/62 (35) 29/179 (16) 3.4 (1.6–7.3) 3.3 (1.6–7.2) 3.6 (1.7–7.7)
p value    0.002 0.002 0.001
  AUC    0.63 (0.56–0.70) 0.64 (0.57–0.71) 0.63 (0.56–0.70)
 Reader 2
  Photopenic or minimal to mild 38/62 (61) 150/179 (84) 1.0 1.0 1.0
  Moderate or marked 24/62 (39) 29/179 (16) 4.8 (2.1–10.8) 4.6 (2.1–10.5) 5.0 (2.2–11.4)
p value    <0.001 <0.001 <0.001
  AUC    0.65 (0.58–0.72) 0.67 (0.60–0.74) 0.65 (0.58–0.72)
Premenopausal women
 Reader 1
  Photopenic or minimal to mild 4/13 (31) 21/38 (55) 1.0 1.0 NA
  Moderate or marked 9/13 (69) 17/38 (45) 2.5 (0.6–10.0) 3.0 (0.7–6.8)  
p value    0.18 0.14  
  AUC    0.63 (0.48–0.78) 0.63 (0.48–0.78)  
 Reader 2
  Photopenic or minimal to mild 2/13 (15) 21/38 (55) 1.0 1.0 NA
  Moderate or marked 11/13 (85) 17/38 (45) 9.4 (1.1–79.5) 10.2 (1.2–90.4)  
p value    0.04 0.04  
  AUC    0.68 (0.54–0.83) 0.74 (0.60–0.87)  
Postmenopausal women
 Reader 1
  Photopenic or minimal to mild 36/49 (73) 129/141 (91) 1.0 1.0 1.0
  Moderate or marked 13/49 (27) 12/141 (9) 3.8 (1.5–9.3) 3.6 (1.5–9.0) 4.1 (1.6–10.3)
p value    0.004 0.006 0.003
  AUC    0.64 (0.56–0.72) 0.65 (0.57–0.73) 0.63 (0.55–0.71)
 Reader 2
  Photopenic or minimal to mild 36/49 (73) 129/141 (91) 1.0 1.0 1.0
  Moderate or marked 13/49 (27) 12/141 (9) 4.1 (1.6–10.2) 4.0 (1.6–9.9) 4.3 (1.7–10.9)
p value    0.002 0.003 0.002
  AUC    0.65 (0.57–0.73) 0.66 (0.58–0.74) 0.64 (0.56–0.72)
  1. BI-RADS Breast Imaging-Reporting and Data System, BMI body mass index, BPU background parenchymal uptake, HRT hormone replacement therapy, NA not applicable
  2. aNumbers in parentheses are percentages
  3. bNumbers in parentheses are 95 % CIs