Table 3 Association of background parenchymal uptake with breast cancer by menopausal status
BPU | Breast cancer casesa | Controlsa | OR adjusted for BMIb | OR adjusted for BMI and BI-RADS densityb | OR adjusted for BMI and postmenopausal HRTb |
|---|---|---|---|---|---|
Overall | |||||
Reader 1 | |||||
Photopenic or minimal to mild | 40/62 (65) | 150/179 (84) | 1.0 | 1.0 | 1.0 |
Moderate or marked | 22/62 (35) | 29/179 (16) | 3.4 (1.6–7.3) | 3.3 (1.6–7.2) | 3.6 (1.7–7.7) |
p value | 0.002 | 0.002 | 0.001 | ||
AUC | 0.63 (0.56–0.70) | 0.64 (0.57–0.71) | 0.63 (0.56–0.70) | ||
Reader 2 | |||||
Photopenic or minimal to mild | 38/62 (61) | 150/179 (84) | 1.0 | 1.0 | 1.0 |
Moderate or marked | 24/62 (39) | 29/179 (16) | 4.8 (2.1–10.8) | 4.6 (2.1–10.5) | 5.0 (2.2–11.4) |
p value | <0.001 | <0.001 | <0.001 | ||
AUC | 0.65 (0.58–0.72) | 0.67 (0.60–0.74) | 0.65 (0.58–0.72) | ||
Premenopausal women | |||||
Reader 1 | |||||
Photopenic or minimal to mild | 4/13 (31) | 21/38 (55) | 1.0 | 1.0 | NA |
Moderate or marked | 9/13 (69) | 17/38 (45) | 2.5 (0.6–10.0) | 3.0 (0.7–6.8) | |
p value | 0.18 | 0.14 | |||
AUC | 0.63 (0.48–0.78) | 0.63 (0.48–0.78) | |||
Reader 2 | |||||
Photopenic or minimal to mild | 2/13 (15) | 21/38 (55) | 1.0 | 1.0 | NA |
Moderate or marked | 11/13 (85) | 17/38 (45) | 9.4 (1.1–79.5) | 10.2 (1.2–90.4) | |
p value | 0.04 | 0.04 | |||
AUC | 0.68 (0.54–0.83) | 0.74 (0.60–0.87) | |||
Postmenopausal women | |||||
Reader 1 | |||||
Photopenic or minimal to mild | 36/49 (73) | 129/141 (91) | 1.0 | 1.0 | 1.0 |
Moderate or marked | 13/49 (27) | 12/141 (9) | 3.8 (1.5–9.3) | 3.6 (1.5–9.0) | 4.1 (1.6–10.3) |
p value | 0.004 | 0.006 | 0.003 | ||
AUC | 0.64 (0.56–0.72) | 0.65 (0.57–0.73) | 0.63 (0.55–0.71) | ||
Reader 2 | |||||
Photopenic or minimal to mild | 36/49 (73) | 129/141 (91) | 1.0 | 1.0 | 1.0 |
Moderate or marked | 13/49 (27) | 12/141 (9) | 4.1 (1.6–10.2) | 4.0 (1.6–9.9) | 4.3 (1.7–10.9) |
p value | 0.002 | 0.003 | 0.002 | ||
AUC | 0.65 (0.57–0.73) | 0.66 (0.58–0.74) | 0.64 (0.56–0.72) | ||