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Fig. 4 | Breast Cancer Research

Fig. 4

From: Raised mammographic density: causative mechanisms and biological consequences

Fig. 4

Fibrillar collagen organisation in low versus high mammographic density (MD) breast. Paraffin section of a low and b high MD breast, stained with picrosirius red (PSR) and visualised using polarised light microscopy. Both tissue samples contain abundant fibrillar collagen (bright features). Scale bar = 20 μm. Polarised light microscopy images of PSR-stained sections of c low and d high MD breast processed using the Image J plugin, OrientationJ. This applies a colour overlay to features of similar alignment, revealing fibril coherency. In this case, the high MD tissue contains many similarly aligned (green) features. Scale bar = 20 μm. Atomic force microscopy (AFM) topography images of regions within low e and high f MD breast. The organisation of collagen fibrils into large bundles in high MD tissues is evident over small length scales. Scale bar = 2 μm

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