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Fig. 9 | Breast Cancer Research

Fig. 9

From: miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells

Fig. 9

High levels of miR-720 are detected in the serum of triple-negative breast cancer (TNBC) patients with higher ADAM8 levels. Sera were obtained from 37 TNBC patients and 15 healthy individuals and analyzed for protein levels of ADAM8 and RNA levels of miR-720. a, b ADAM8 protein levels were measured by ELISA in serum samples from TNBC patients and healthy individuals (a). TNBC patients were separated based on their ADAM8 levels: high ADAM8 > 100 pg/ml and low ADAM8 < 100 pg/ml (b). c Total RNA was collected from serum samples and miR-720 levels were determined using RT-qPCR. Relative miR-720 levels in serum of TNBC patients with high ADAM8, low ADAM8 and normal individuals are presented. *P <0.05, ***P < 0.001, ****P < 0.0001, Welch’s t test. NS not significant

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