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Fig. 8 | Breast Cancer Research

Fig. 8

From: miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells

Fig. 8

miR-720 is detected in the plasma of mice before tumors become palpable. MDA-MB-231 shCtrl-3 cells (2.5 × 106 in 40 μl 50 % Matrigel) were implanted on day 1 into the mammary fat pad of female mice (n = 5). Tumor volume was measured on the indicated days. Blood was collected on the day prior to implantation and on day 7 by submandibular bleeding and centrifuged to obtain clear plasma. Total RNA was collected from plasma samples and miR-720 levels were determined using RT-qPCR. a Tumor growth in individual mice from day 1 to day 21. Tumor volume (cm3) is presented. b Relative miR-720 levels in plasma of the individual mice at day 0 and day 7. **P < 0.005, Student’s t test

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