Fig. 6
From: Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition
Schematic model of IGF1R-evoked and p110β-evoked resistance to p110α inhibition in PIK3CA mutant breast cancer cells. Schematics illustrating a the steady state of the PI3K pathway in PIK3CA mutant breast cancer, and b the identified feedback loop triggered by inhibition of p110α (BYL719) and offset by c IGF1R (AEW541) or d p110β (AZD6482) inhibition at the cellular level. IGF1R insulin growth factor receptor, mTOR mechanistic target of rapamycin, PI3K phosphatidylinositol 3-kinase