Fig. 6
From: COX-2 modulates mammary tumor progression in response to collagen density
Regulation of fibroblasts by collagen density and celecoxib. a, b Immunofluorescence images of vimentin+ fibroblasts or alpha smooth muscle actin (α-SMA)+ fibroblasts (magenta) counterstained with 4',6-diamidino-2-phenylindole (DAPI) (green); ×20 objective; scale bar = 100 um. c The number of vimentin+ fibroblasts remains the same regardless of collagen density. Values represent vimentin+ cells normalized to total cell number. d Celecoxib (Clxb) decreases the number of α-SMA+ fibroblasts in the stroma of PyMT/Col1a1 tumors. Values represent the number of α-SMA+ cells normalized to the total number of cells. Raw data are depicted; *p < 0.05; n = 5 mice per arm; at least 8 image fields analyzed per 2–3 tumors per animal; mixed linear model. Veh vehicle