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Fig. 3 | Breast Cancer Research

Fig. 3

From: COX-2 modulates mammary tumor progression in response to collagen density

Fig. 3

Regulation of cytokines by celecoxib in PyMT and PyMT/Col1a1 tumors. Several cytokines are upregulated in PyMT/Col1a1 (HD) mammary tumors compared to PyMT (wild-type (WT)) tumors. Treatment with celecoxib (CLXB) diminishes cytokine levels in PyMT (WT) and PyMT/Col1a1 (HD) mice. Relative levels of cytokines are represented as the fold-change normalized to PyMT (WT) vehicle (VEH). Cytokines with equal to or greater than a two-fold change are considered significantly upregulated. Three tumors, each from a single animal, were pooled per treatment arm to perform the multiplex cytokine ELISA array. TNFα tumor necrosis factor alpha, IGF insulin growth factor, VEGF vascular endothelial growth factor, IL interleukin, FGFβ fibroblast growth factor beta, IFNy interferon gamma, EGF epithelial growth factor, G-CSF granulocyte-colony stimulating factor (CSF-2), GM-CSF granulocyte-macrophage colony-stimulating factor (CSF-3), MCP-1 monocyte chemotactic protein 1 (CCL2), MIP-1α macrophage inflammatory protein 1 alpha (CCL3), SCF stem cell factor, RANTES regulated on activation, normal T cell expressed and secreted (CCL5), PDGF-ββ platelet-derived growth factor beta-beta, β-NGF nerve growth factor beta

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