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Table 7 Summary of selected studies investigating differential features of fibroadenomas and phyllodes tumors on pre-operative materials

From: A five-gene reverse transcription-PCR assay for pre-operative classification of breast fibroepithelial lesions

Author N Assessment approach Key findings
Jacobs [16] 16 FAs
12 PTs
Histology
Immunohistochemistry
Stromal cellularity, mitoses, expression of Ki-67 and topoisomerase IIα might help determining phyllodes tumors
Lee [11] 38 FAs
44 PTs
Histology Features indicating phyllodes tumors:
(1) increased stromal cellularity in at least 50 % of the specimen; (2) stromal overgrowth; (3)fragmentation and; 4) presence of adipose tissue within stroma
Jara-Lazaro [15] 21 FAs
36 PTs
Histology
Immunohistochemistry
(1) Marked stromal hypercellularity and nuclear atypia, stromal overgrowth, and ill-defined lesional margins exclusively predicted phyllodes tumor on excision.
(2) Expression of Ki67 ≥ 5 %, topoisomerase IIα ≥ 5 % and reduced CD34 correlates significantly with phyllodes tumors.
Morgan [12] 91a FAs
21 PTs
Histology Proposed two putative predictive tools:
(1) Logit P(x) = − 0.9014 (age) − 3.61 (mitosis) + 11.156
(2) Z = 0.8909(age) + 0.0347(% stroma) + 0.5274 (mitoses/10HPF)
Yasir [13] 37 FAs
27 PTs
Histology Stromal mitoses and/or three or more histological features were helpful in predicting phyllodes tumors on excisions.
  1. FAs fibroadenomas, PTs phyllodes tumors
  2. aDiagnoses not confirmed on excisions