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Table 5 Seventeen cases with discordant outcomes between the five-gene assay and pathological diagnosis in the validation cohort. Post-operative diagnoses were used as benchmark reference unless otherwise stated

From: A five-gene reverse transcription-PCR assay for pre-operative classification of breast fibroepithelial lesions

Sample ID Five-gene assay Pathological diagnosis
CB22 FA Benign PTa
CB116 FA Benign PT
CB95 FA Benign PT
CB28 FA Benign PTa
CB68 FA Benign PTa
CB120 FA Borderline PTa
CB130 FA Borderline PT
CB26 PT Cellular FA
CB77 PT FA
CB24 PT FA
CB29 PT FA
CB82 PT FA
CB126 PT FA
CB144 PT FAb,c
CB184 PT FAb,c
CB251 PT FAb
CB258 PT FAb,d
  1. FA fibroadenoma, PT phyllodes tumor
  2. aPre-operative pathological diagnoses were inconclusive or discordant with post-operative pathological diagnoses (see Table 6 asterisked cases)
  3. bCases of core biopsies without subsequent surgical excisions. Outcome of the five-gene assay was benchmarked against the pre-operative pathological diagnosis
  4. cFeatures in keeping with fibroadenoma with hyalinized leafy fronds noted albeit without stromal cellularity
  5. dFocal areas of hemorrhage and high cellularity, diagnosis could not be definitively concluded on review