A five-gene reverse transcription-PCR assay for pre-operative classification of breast fibroepithelial lesions

Breast Cancer Research

Table 5 Seventeen cases with discordant outcomes between the five-gene assay and pathological diagnosis in the validation cohort. Post-operative diagnoses were used as benchmark reference unless otherwise stated

FA fibroadenoma, PT phyllodes tumor
^aPre-operative pathological diagnoses were inconclusive or discordant with post-operative pathological diagnoses (see Table 6 asterisked cases)
^bCases of core biopsies without subsequent surgical excisions. Outcome of the five-gene assay was benchmarked against the pre-operative pathological diagnosis
^cFeatures in keeping with fibroadenoma with hyalinized leafy fronds noted albeit without stromal cellularity
^dFocal areas of hemorrhage and high cellularity, diagnosis could not be definitively concluded on review

ISSN: 1465-542X