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Table 4 Performance of the five-gene model in predicting diagnosis in the independent validation cohort of 230 core biopsies

From: A five-gene reverse transcription-PCR assay for pre-operative classification of breast fibroepithelial lesions

  Diagnosis from pathological report  
Predicted outcome from the five-gene assay Fibroadenomas Phyllodes tumors  
Fibroadenomas 179 7 NPV = 0.962
Phyllodes tumors 10 34 PPV = 0.773
  Spec = 0.947 Sen = 0.829  
  1. The five-gene assay has an overall accuracy of 92.6 %, with a sensitivity (sen) of 82.9 % and specificity (spec) of 94.7 %. The positive predictive value (PPV) and negative predictive value (NPV) are 77.3 % and 96.2 % respectively