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Table 2 HER2, ER and PR status and malignancy features of DMBA-induced mammary gland tumors in WT, CORT-KO and SST-KO mice

From: Lack of cortistatin or somatostatin differentially influences DMBA-induced mammary gland tumorigenesis in mice in an obesity-dependent mode

Group Histological type HER2a ER PR Ki 67 Mitosisb Inflammationc Angiogenesisc
WT LF Undifferentiated carcinoma 1+ Negative Positive Positive - 10 1/3 1/3
Undifferentiated carcinoma 1+ Negative Positive Negative - 12 1/3 2/3
Well-differentiated squamous carcinoma 1+ Negative Positive - - 9 2/3 1/3
WT HF Undifferentiated carcinoma 0 Negative Positive Negative - 11 0/3 1/3
Moderately differentiated adenocarcinoma 1+ Negative Positive Negative 40 % 6 1/3 1/3
CORT-KO LF Undifferentiated carcinoma 0 Negative Positive Positive 65 % 12 1/3 1/3
Undifferentiated carcinoma 0 Negative Positive Positive 70 % 19 1/3 2/3
Undifferentiated carcinoma 0 Negative Positive - 65 % 5 1/3 1/3
Undifferentiated carcinoma 1+ Negative Positive Negative - 5 1/3 2/3
Undifferentiated carcinoma 1+ Negative Negative - - 5 2/3 1/3
Undifferentiated carcinoma 1+ Negative Positive Negative - 8 0/3 1/3
Undifferentiated carcinoma 0 Negative Positive Positive 70 % 7 1/3 1/3
Well-differentiated squamous carcinoma 1+ Negative Positive Positive 70 % 9 1/3 1/3
Well-differentiated squamous carcinoma 1+ Negative Positive Positive 90 % 10 1/3 1/3
Well-differentiated squamous carcinoma 1+ Negative - Positive 70 % 8 1/3 1/3
CORT-KO HF Undifferentiated carcinoma 0 Negative Positive Negative 75 % 12 2/3 1/3
Undifferentiated carcinoma 0 Negative Positive Positive - 6 1/3 1/3
Well-differentiated squamous carcinoma 2+ Positive Positive Negative 70 % 13 2/3 1/3
Moderately differentiated squamous carcinoma 1+ Negative Positive Positive - 2 3/3 2/3
SST-KO HF Undifferentiated carcinoma 1+ Negative Positive - 50 % 7 1/3 1/3
Undifferentiated carcinoma 1+ Negative Positive Negative 80 % 19 1/3 2/3
Well-differentiated squamous carcinoma 2+ Positive Positive Positive 75 % 10 1/3 1/3
  1. aPresence of human epidermal growth factor receptor-2 (HER2) was evaluated as negative (0: negative staining or, 1+: >10 % of cells with incomplete or undetectable staining) or positive (2+: >10 % of cells with complete staining). bNumber of mitotic cells per each 10 high power fields. cInflammation and de novo angiogenesis were valued as 0/3 (no inflammation), 1/3 (scarce), 2/3 (moderate) or 3/3 (abundant). ER estrogen receptor, PR progesterone receptor, WT wild-type, HF high fat, LF low fat, CORT-KO cortistatin knockout, SST-KO somatostatin knockout