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Table 2 HER2, ER and PR status and malignancy features of DMBA-induced mammary gland tumors in WT, CORT-KO and SST-KO mice

From: Lack of cortistatin or somatostatin differentially influences DMBA-induced mammary gland tumorigenesis in mice in an obesity-dependent mode

Group

Histological type

HER2a

ER

PR

Ki 67

Mitosisb

Inflammationc

Angiogenesisc

WT LF

Undifferentiated carcinoma

1+ Negative

Positive

Positive

-

10

1/3

1/3

Undifferentiated carcinoma

1+ Negative

Positive

Negative

-

12

1/3

2/3

Well-differentiated squamous carcinoma

1+ Negative

Positive

-

-

9

2/3

1/3

WT HF

Undifferentiated carcinoma

0 Negative

Positive

Negative

-

11

0/3

1/3

Moderately differentiated adenocarcinoma

1+ Negative

Positive

Negative

40 %

6

1/3

1/3

CORT-KO LF

Undifferentiated carcinoma

0 Negative

Positive

Positive

65 %

12

1/3

1/3

Undifferentiated carcinoma

0 Negative

Positive

Positive

70 %

19

1/3

2/3

Undifferentiated carcinoma

0 Negative

Positive

-

65 %

5

1/3

1/3

Undifferentiated carcinoma

1+ Negative

Positive

Negative

-

5

1/3

2/3

Undifferentiated carcinoma

1+ Negative

Negative

-

-

5

2/3

1/3

Undifferentiated carcinoma

1+ Negative

Positive

Negative

-

8

0/3

1/3

Undifferentiated carcinoma

0 Negative

Positive

Positive

70 %

7

1/3

1/3

Well-differentiated squamous carcinoma

1+ Negative

Positive

Positive

70 %

9

1/3

1/3

Well-differentiated squamous carcinoma

1+ Negative

Positive

Positive

90 %

10

1/3

1/3

Well-differentiated squamous carcinoma

1+ Negative

-

Positive

70 %

8

1/3

1/3

CORT-KO HF

Undifferentiated carcinoma

0 Negative

Positive

Negative

75 %

12

2/3

1/3

Undifferentiated carcinoma

0 Negative

Positive

Positive

-

6

1/3

1/3

Well-differentiated squamous carcinoma

2+ Positive

Positive

Negative

70 %

13

2/3

1/3

Moderately differentiated squamous carcinoma

1+ Negative

Positive

Positive

-

2

3/3

2/3

SST-KO HF

Undifferentiated carcinoma

1+ Negative

Positive

-

50 %

7

1/3

1/3

Undifferentiated carcinoma

1+ Negative

Positive

Negative

80 %

19

1/3

2/3

Well-differentiated squamous carcinoma

2+ Positive

Positive

Positive

75 %

10

1/3

1/3

  1. aPresence of human epidermal growth factor receptor-2 (HER2) was evaluated as negative (0: negative staining or, 1+: >10 % of cells with incomplete or undetectable staining) or positive (2+: >10 % of cells with complete staining). bNumber of mitotic cells per each 10 high power fields. cInflammation and de novo angiogenesis were valued as 0/3 (no inflammation), 1/3 (scarce), 2/3 (moderate) or 3/3 (abundant). ER estrogen receptor, PR progesterone receptor, WT wild-type, HF high fat, LF low fat, CORT-KO cortistatin knockout, SST-KO somatostatin knockout