Table 2 A short overview of the most common breast cancer cell lines and their origin
Cell line (ATCC) | Origin | Carcinoma/normal | Clinic-pathology |
|---|---|---|---|
MCF-7 (HTB-22) | pleural effusion | adenocarcinoma | luminal A |
T47D (HTB-133) | pleural effusion | ductal carcinoma | luminal A (ER+, Her2–) |
MDA-MB-134 (HTB-23) | pleural effusion | ductal carcinoma | epithelial |
MDA-MB-231 (HTB-26) | pleural effusion | adenocarcinoma | Claudin low (ER–) |
MDA-MB-436 (HTB-130) | pleural effusion | adenocarcinoma | pleomorphic and multinucleated |
MDA-MB-453 (HTB-131) | pericardial effusion | metastatic carcinoma | epithelial |
MDA-MB-468 (HTB-132) | pleural effusion | adenocarcinoma | basal (ER–, EGFR++) |
CAMA-1 (HTB-21) | pleural effusion | adenocarcinoma | epithelial |
SK-BR-3 (HTB-30) | pleural effusion | adenocarcinoma | Her2+ (ER–) |
HCC1428 (CRL-2327) | pleural effusion | adenocarcinoma | epithelial (ER+, Her2–) |
SUM149PT | breast | inflammatory carcinoma | basal B (ER-, PR–) |
SUM190PT | breast | inflammatory carcinoma | luminal (ER–, PR–, Her2+) |
BT-20 (HTB-19) | breast | ductal carcinoma | epithelial (ER–, EGFR++) |
BT-157 (HTB-122) | breast | ductal carcinoma | mesenchymal (ER–) |
BT-474 (HTB-20) | breast ducts | ductal carcinoma | luminal B (ER+, Her2+) |
Hs578T (HTB-126) | breast | carcinoma | luminal A (ER–) |
HCC1954 (CRL-2338) | breast ducts | ductal carcinoma | epithelial (ER-, HER2++) |
HCC1143 (CRL-2321) | breast ducts | ductal carcinoma | epithelial (ER–) |
MCF10A (CRL-10317) | breast | normal | epithelial adherent |
MCF10F (CRL-10318) | breast (see MCF10A) | normal | epithelial floating |
hTERT-HME1 (CRL-4010) | breast | normal | epithelial |