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Table 1 Overview of studies that compared surgery with radiotherapy alone after neoadjuvant chemotherapy

From: Selective elimination of breast cancer surgery in exceptional responders: historical perspective and current trials

Study Study period n cCR Locoregional treatment 5-year overall survival 5-year LRR
     Surgery RT alone Surgery (%) RT alone (%) Surgery (%) RT alone (%)
De Lena et al. [11] 1975–1980 prospective 132 T3b-4 N0-2 100 % RT group; 60 % surgery group 65 67 49.1a 51.7a 29.6 31.1
Perloff et al. [9] 1978–1983 prospective 87 18 % 43 44 63b 50b 19 27
Scholl et al. [8] 1986–1990 200 ? 36 Mtx ± RT, 62 BCS + RT 102 24  
Touboul et al. [6] 1982–1990 prospective 97 33 37 rD (>3 cm), Mtx; 27 rD (<3 cm), BCS 33 83.3 75.7 16 after BCS, 5.4 after Mtx 16
Ellis et al. [12] 1985–1994 185 39 120; 29 Mtx, 91 BCS 39 76 84 7 21
Mauriac et al. [7] 1985–1989 134 T2-3   89; 40 BCS = RT, 49 Mtx 44 22.5 BCS + RT, 22.4 after Mtx 34
Ring et al. [13] 1986–1999 453 136 67 69 74 76 10 21
Daveau et al. [10] 1985–1999 1477 T2-3 165 65 100 82 91 12 23
  1. aFour-year overall survival
  2. bOverall survival at 39 months
  3. BCS breast conserving surgery, cCR clinical complete remission, LRR locoregional recurrence, Mtx mastectomy, rD residual disease, RT radiotherapy