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Fig. 8 | Breast Cancer Research

Fig. 8

From: Interferon-induced transmembrane protein 1 (IFITM1) overexpression enhances the aggressive phenotype of SUM149 inflammatory breast cancer cells in a signal transducer and activator of transcription 2 (STAT2)-dependent manner

Fig. 8

Activation of type I interferon (IFN) signaling pathway by exogenous IFNα in SUM149 and SUM190 cells. a Effects of IFN induction on the protein levels of IFN-stimulated genes (IFITM1, STAT1, p-STAT1, STAT2, and p-STAT2) in the SUM149 and SUM190 cells. β-Actin was used as a loading control. b Cellular localization and expression of interferon-induced transmembrane protein 1 (IFITM1) protein in SUM149 and SUM190 cells following IFN induction. Immunofluorescence was used to assess IFITM1 expression and localization in the cells that were induced with IFNα for 24 h as compared with the control. The images were captured using Leica confocal microscope. DAPI 4′,6-diamidino-2-phenylindole, STAT signal transducer and activator of transcription

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Breast Cancer Research

ISSN: 1465-542X

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