TY - JOUR AU - Ogony, Joshua AU - Choi, Hye Joung AU - Lui, Asona AU - Cristofanilli, Massimo AU - Lewis-Wambi, Joan PY - 2016 DA - 2016/02/20 TI - Interferon-induced transmembrane protein 1 (IFITM1) overexpression enhances the aggressive phenotype of SUM149 inflammatory breast cancer cells in a signal transducer and activator of transcription 2 (STAT2)-dependent manner JO - Breast Cancer Research SP - 25 VL - 18 IS - 1 AB - Inflammatory breast cancer (IBC) is a very aggressive and lethal subtype of breast cancer that accounts for about 4 % of all breast cancers diagnosed in the United States. Despite the efforts of several investigators to identify the molecular factors driving the aggressive phenotype of IBC, a great deal is still unknown about the molecular underpinnings of the disease. In the present study, we investigated the role of interferon-induced transmembrane protein 1 (IFITM1), a well-known interferon-stimulated gene (ISG), in promoting the aggressiveness of SUM149 IBC cells. SN - 1465-542X UR - https://doi.org/10.1186/s13058-016-0683-7 DO - 10.1186/s13058-016-0683-7 ID - Ogony2016 ER -