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Table 3 Associations between IGF levels and TDLU count among women with benign breast disease, overall and stratified by menopausal status

From: Circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3 and terminal duct lobular unit involution of the breast: a cross-sectional study of women with benign breast disease

  All women Premenopausala Postmenopausalb
IGF measurec Number RR (95 % CI) Number RR (95 % CI) Number RR (95 % CI)
IGF-I       
 Tertile 1 (ref.) 76 1 52 1 25 1
 Tertile 2 76 1.12 (1.01–1.23) 52 0.95 (0.85–1.06) 24 1.02 (0.83–1.26)
 Tertile 3 76 1.31 (1.18–1.45) 51 1.00 (0.90–1.13) 24 1.26 (1.06–1.50)
P-trend <0.0001 0.89 0.009
IGFBP-3       
 Tertile 1 (ref.) 74 1 52 1 24 1
 Tertile 2 76 1.03 (0.94–1.13) 52 0.94 (0.84–1.05) 24 0.57 (0.46–0.71)
 Tertile 3 76 0.88 (0.80–0.96) 51 1.00 (0.90–1.11) 24 0.56 (0.45–0.70)
P-trend 0.009 0.99 <0.0001
IGF-I:IGFBP-3 molar ratio       
 Tertile 1 (ref.) 75 1 52 1 24 1
 Tertile 2 76 1.44 (1.29–1.60) 52 1.14 (1.01–1.28) 24 1.69 (1.28–2.23)
 Tertile 3 75 1.84 (1.65–2.06) 51 1.17 (1.04–1.32) 24 2.78 (2.14–3.62)
P-trend <0.0001 0.01 <0.0001
  1. Terminal duct lobular unit (TDLU) count refers to numbers of TDLUs per unit of tissue area. Relative risk (RR) and 95 % CI were estimated using zero-inflated Poisson regression analysis. Analyses among all women were adjusted for covariates included in both the premenopausal and postmenopausal women. P value for trend (P-trend) was calculated using the Wald test. aFully adjusted models for premenopausal women included body mass index (BMI), age at first birth, percent fat on the tissue slide and age at biopsy. bFully adjusted models for postmenopausal women included covariates in premenopausal women in addition to age at menarche and an interaction term for BMI and percent fat on the tissue slide. Note: analyses of insulin-like growth factor binding protein-3 (IGFBP-3) and the molar ratio in postmenopausal women and all women combined were additionally adjusted for age at menarche. Two women, one premenopausal and one postmenopausal, were missing data on this risk factor and were not included. cTertiles (T) for all women: insulin-like growth factor (IGF-I) (T1, <103; T2, 103 to <128; T3, 128+ ng/ml); IGFBP-3 (T1, <3,110; T2, 3,110 to <3,677; T3, 3,677+ ng/ml); molar ratio (T1, <0.113; T2, 0.113 to <0.133; T3, 0.133+). Tertiles for premenopausal women: IGF-I (T1, <107; T2, 107 to <132.3; T3, 132.3+ ng/ml); IGFBP-3 (T1, <3,079; T2, 3,079 to <3,668; T3, 3,668+ ng/ml); molar ratio (T1, <0.119; T2, 0.119 to <0.140; T3, 0.140+). Tertiles for postmenopausal women: IGF-I (T1, <93; T2, 93 to <122; T3, 122+ ng/ml); IGFBP-3 (T1, <3,214; T2, 3,214 to <3,838; T3, 3,839+ ng/ml); molar ratio (T1, <0.102; T2, 0.102 to <0.1205; T3, 0.1205+).