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Table 2 Distribution of IGF levels and TDLU characteristics among women with benign breast disease, stratified by menopausal status

From: Circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3 and terminal duct lobular unit involution of the breast: a cross-sectional study of women with benign breast disease

  All women (n = 228) Premenopausal (n = 155) Postmenopausal (n = 73)  
  Median Range Correlation with density, r Adj. correlation with density, r Median Range Correlation with density, r Adj. correlation with density, r Median Range Correlation with density, r Adj. correlation with density, r P valuea
IGF measures              
 IGF-I (ng/ml) 116.15 20.68–250.85 0.08 −0.11 119.4 55.69–250.85 0.0001 −0.11 110.87 20.68–213.43 −0.05 −0.09 0.001
 IGFBP-3 (ng/ml) 3451.25 1165.0–4926.5 −0.22** −0.14* 3419.5 1784.5–4926.5 −0.25** −0.13 3467 1165.0–4878.5 −0.18 −0.12 0.44
 IGF-I:IGFBP-3 Molar ratio 0.122 0.062–0.268 0.27** −0.03 0.13 0.071–0.074 0.20* −0.05 0.11 0.062–0.189 0.08 −0.01 0.0001
Lobular involution Measures              
 TDLU countb 4 0–100 0.22* 0.02 5 0–100 0.21* 0.005 3 0–79 0.14 0.02 0.16
 Median TDLU span, μm 266 78–1030 0.17* 0.08 292 78–1030 0.14 0.08 202 83–568 −0.17 −0.001 0.0001
 Median category of acini counts per TDLU 1 1–6 0.09 0.03 1 1–6 0.11 0.04 1 1–5 −0.10 −0.008 0.35
  1. Correlation between insulin-like growth factor (IGF) and involution measures (continuous) with percent volumetric mammographic density was calculated using Spearman partial rank-order correlation. Adjusted (Adj.) correlation was calculated after removing the effects of age and body mass index. *P <0.05, **P <0.001. a P values comparing levels of IGFs for premenopausal and postmenopausal women were calculated using Kruskal–Wallis rank test. bTerminal duct lobular unit (TDLU) count refers to numbers of TDLUs per unit of tissue area. r Spearman rho, IGFBP-3 insulin-like growth factor binding protein-3