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Table 1 Percentages of apoptotic cells following a 72-h epirubicin treatment

From: Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer

Cell line

Control

Epirubicin concentration

MDA-MB-231

DMSO

1 nM

25 nM

1000 nM

Native

18 %

17 %

41 %

94 %

25 nM-R

10 %

10 %

8 %

50 %

MCF7

DMSO

1 nM

30 nM

1000 nM

Native

32 %

29 %

49 %

77 %

30 nM-R

20 %

24 %

23 %

78 %

SKBR3

DMSO

1 nM

15 nM

1000 nM

Native

22 %

26 %

24 %

59 %

15 nM-R

18 %

17 %

17 %

34 %

ZR-72-1

DMSO

1 nM

10 nM

1000 nM

Native

36 %

44 %

47 %

71 %

10 nM-R

29 %

28 %

29 %

62 %

  1. DMSO dimethyl sulphoxide; DRFS, distant relapse-free survival
  2. Apoptotic cells = annexin V–positive. Debris and necrotic cells (annexin V–negative, 7-aminoactinomycin D–positive) were gated out. Percentages reported are derived from a single experiment; at least two independent experiments were done for each cell line
  3. Bold data denotes the different concentrations of epirubicin used for each cell line