Skip to main content

Table 2 Association between rs75915166 or rs554219 and grade in ductal carcinoma in situ

From: Genetic predisposition to ductal carcinoma in situ of the breast

  Meta-analysis
OR (95 % CI) P Low/intermediate grade, number High grade, number Controls, number
rs75915166      
Low/intermediate grade vs controls 1.36 (1.17, 1.59) 7.2 × 10-5 1,465   35,521
High grade vs controls 0.92 (0.79, 1.08) 0.31   1,941 32,202
Case-only high vs low/intermediate grade      
  Unadjusted 0.68 (0.55, 0.83) 1.4 × 10-4 1,307 1,941  
  unadjusted (only cases with ER status) 0.65 (0.51, 0.84) 1.1 × 10-3 791 1,360  
  adjusted for ER status 0.68 (0.52, 0.89) 0.0050 791 1,360  
  ER+ only 0.68 (0.55, 0.84) 5 × 10-4 709 985  
rs554219      
Low/intermediate grade vs controls 1.32 (1.18, 1.48) 8.2 × 10-7 1,465   35,521
High grade vs controls 1.02 (0.91, 1.14) 0.75   1,941 32,202
Case-only high vs low/intermediate grade      
  Unadjusted 0.75 (0.65, 0.87) 1.3 × 10-4 1,307 1,941  
  unadjusted (only cases with ER status) 0.75 (0.63, 0.88) 2.1 × 10-4 791 1,360  
  adjusted for ER status 0.80 (0.67, 0.96) 0.019 792 1,360  
  ER+ only 0.76 (0.65, 0.89) 6.7 × 10-4 709 985  
  1. OR odds ratio, ER estrogen receptor