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Table 2 Association between rs75915166 or rs554219 and grade in ductal carcinoma in situ

From: Genetic predisposition to ductal carcinoma in situ of the breast

 

Meta-analysis

OR (95 % CI)

P

Low/intermediate grade, number

High grade, number

Controls, number

rs75915166

     

Low/intermediate grade vs controls

1.36 (1.17, 1.59)

7.2 × 10-5

1,465

 

35,521

High grade vs controls

0.92 (0.79, 1.08)

0.31

 

1,941

32,202

Case-only high vs low/intermediate grade

     
 

Unadjusted

0.68 (0.55, 0.83)

1.4 × 10-4

1,307

1,941

 
 

unadjusted (only cases with ER status)

0.65 (0.51, 0.84)

1.1 × 10-3

791

1,360

 
 

adjusted for ER status

0.68 (0.52, 0.89)

0.0050

791

1,360

 
 

ER+ only

0.68 (0.55, 0.84)

5 × 10-4

709

985

 

rs554219

     

Low/intermediate grade vs controls

1.32 (1.18, 1.48)

8.2 × 10-7

1,465

 

35,521

High grade vs controls

1.02 (0.91, 1.14)

0.75

 

1,941

32,202

Case-only high vs low/intermediate grade

     
 

Unadjusted

0.75 (0.65, 0.87)

1.3 × 10-4

1,307

1,941

 
 

unadjusted (only cases with ER status)

0.75 (0.63, 0.88)

2.1 × 10-4

791

1,360

 
 

adjusted for ER status

0.80 (0.67, 0.96)

0.019

792

1,360

 
 

ER+ only

0.76 (0.65, 0.89)

6.7 × 10-4

709

985

 
  1. OR odds ratio, ER estrogen receptor