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Table 1 Loci showing a significant association with ductal carcinoma in situ (DCIS) at P <0.00066

From: Genetic predisposition to ductal carcinoma in situ of the breast

Chromosome SNP Locus RAF DCIS vs controls (meta-analysis) IDC vs controls Case-only DCIS vs IDC
    Controls OR (95 % CI) P OR (95 % CI) P P-Het
10 rs2981579 FGFR2 0.40 1.29 (1.24, 1.35) 9.0 × 10-30 1.24 (1.21, 1.28) 6.1 × 10-66 0.14
10 rs2981582 FGFR2 0.38 1.28 (1.23, 1.34) 1.8 × 10-27 1.23 (1.20, 1.26) 2.1 × 10-59 0.21
16 rs3803662 TOX3 0.26 1.15 (1.10, 1.21) 1.7 × 10-8 1.23 (1.20, 1.27) 1.5 × 10-50 0.69
5 rs889312 MAP3K1 0.28 1.14 (1.09, 1.20) 6.9 × 10-8 1.11 (1.08, 1.14) 2.2 × 10-14 0.13
3 rs4973768 SLC4A7 0.47 1.13 (1.08, 1.18) 9.1 × 10-8 1.09 (1.07, 1.12) 8.2 × 10-13 0.58
5 rs10941679 5p12 0.25 1.14 (1.09, 1.20) 1.3 × 10-7 1.14 (1.11, 1.18) 1.2 × 10-20 0.90
3 rs3821902 ATXN7 0.13 1.16 (1.09, 1.23) 3.0 × 10-6 1.06 (1.02, 1.09) 0.0030 0.33
19 rs4808801 SSBP4 0.65 1.12 (1.06, 1.18) 3.1 × 10-6 1.09 (1.05, 1.11) 3.5 × 10-9 0.16
10 rs10995190 ZNF365 0.85 1.16 (1.09, 1.23) 4.1 × 10-6 1.15 (1.11, 1.19) 7.5 × 10-16 0.61
2 rs13387042 2q35 0.51 1.10 (1.05, 1.15) 1.1 × 10-5 1.14 (1.11, 1.16) 8.3 × 10-25 0.34
6 rs3757318 ESR1 0.07 1.20 (1.10, 1.30) 1.4 × 10-5 1.16 (1.10, 1.21) 1.2 × 10-9 0.85
11 rs554219 CCND1 0.12 1.15 (1.08, 1.22) 2.8 × 10-5 1.27 (1.22, 1.32) 6.4 × 10-38 0.88
6 rs2046210 ESR1 0.34 1.10 (1.05, 1.15) 8.6 × 10-5 1.09 (1.06, 1.12) 4.0 × 10-10 0.32
12 rs10771399 PTHLH 0.88 1.15 (1.06, 1.23) 0.00021 1.18 (1.12, 1.22) 1.2 × 10-14 0.53
8 rs11780156 8q24.21 0.16 1.11 (1.05, 1.18) 0.00027 1.10 (1.06, 1.14) 2.3 × 10-8 0.88
16 rs17817449 FTO 0.60 1.09 (1.03, 1.14) 0.00052 1.06 (1.04, 1.10) 5.9 × 10-7 0.32
  1. SNP single nucleotide polymorphism, IDC invasive ductal carcinoma, OR odds ratio; P-Het P value for heterogeneity; RAF risk allele frequency