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Table 1 Loci showing a significant association with ductal carcinoma in situ (DCIS) at P <0.00066

From: Genetic predisposition to ductal carcinoma in situ of the breast

Chromosome

SNP

Locus

RAF

DCIS vs controls (meta-analysis)

IDC vs controls

Case-only DCIS vs IDC

   

Controls

OR

(95 % CI)

P

OR

(95 % CI)

P

P-Het

10

rs2981579

FGFR2

0.40

1.29

(1.24, 1.35)

9.0 × 10-30

1.24

(1.21, 1.28)

6.1 × 10-66

0.14

10

rs2981582

FGFR2

0.38

1.28

(1.23, 1.34)

1.8 × 10-27

1.23

(1.20, 1.26)

2.1 × 10-59

0.21

16

rs3803662

TOX3

0.26

1.15

(1.10, 1.21)

1.7 × 10-8

1.23

(1.20, 1.27)

1.5 × 10-50

0.69

5

rs889312

MAP3K1

0.28

1.14

(1.09, 1.20)

6.9 × 10-8

1.11

(1.08, 1.14)

2.2 × 10-14

0.13

3

rs4973768

SLC4A7

0.47

1.13

(1.08, 1.18)

9.1 × 10-8

1.09

(1.07, 1.12)

8.2 × 10-13

0.58

5

rs10941679

5p12

0.25

1.14

(1.09, 1.20)

1.3 × 10-7

1.14

(1.11, 1.18)

1.2 × 10-20

0.90

3

rs3821902

ATXN7

0.13

1.16

(1.09, 1.23)

3.0 × 10-6

1.06

(1.02, 1.09)

0.0030

0.33

19

rs4808801

SSBP4

0.65

1.12

(1.06, 1.18)

3.1 × 10-6

1.09

(1.05, 1.11)

3.5 × 10-9

0.16

10

rs10995190

ZNF365

0.85

1.16

(1.09, 1.23)

4.1 × 10-6

1.15

(1.11, 1.19)

7.5 × 10-16

0.61

2

rs13387042

2q35

0.51

1.10

(1.05, 1.15)

1.1 × 10-5

1.14

(1.11, 1.16)

8.3 × 10-25

0.34

6

rs3757318

ESR1

0.07

1.20

(1.10, 1.30)

1.4 × 10-5

1.16

(1.10, 1.21)

1.2 × 10-9

0.85

11

rs554219

CCND1

0.12

1.15

(1.08, 1.22)

2.8 × 10-5

1.27

(1.22, 1.32)

6.4 × 10-38

0.88

6

rs2046210

ESR1

0.34

1.10

(1.05, 1.15)

8.6 × 10-5

1.09

(1.06, 1.12)

4.0 × 10-10

0.32

12

rs10771399

PTHLH

0.88

1.15

(1.06, 1.23)

0.00021

1.18

(1.12, 1.22)

1.2 × 10-14

0.53

8

rs11780156

8q24.21

0.16

1.11

(1.05, 1.18)

0.00027

1.10

(1.06, 1.14)

2.3 × 10-8

0.88

16

rs17817449

FTO

0.60

1.09

(1.03, 1.14)

0.00052

1.06

(1.04, 1.10)

5.9 × 10-7

0.32

  1. SNP single nucleotide polymorphism, IDC invasive ductal carcinoma, OR odds ratio; P-Het P value for heterogeneity; RAF risk allele frequency