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Table 1 Effect of fibroblast Tiam1 on tumor-initiating ability of post-co-culture breast cancer cells in primary (A) and passaged (B) mouse xenografts

From: The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis

  1. Results are shown as: #tumor-bearing mice/total mice (#tumors/#xenograft implantations)
  2. P values calculated by t test
  3. PCC post-co-culture, RMF reduction mammary fibroblast
  4. A. Primary xenografts were established with SUM1315 breast cancer cells under conditions of limiting dilution after isolation from 3D co-cultures with indicated mammary fibroblasts. B. Secondary passaged xenografts were established in serial dilution with single cell suspensions of primary tumors established in A, taken from the 106 cell implantation and matched for size and weight