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Fig. 2 | Breast Cancer Research

Fig. 2

From: The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis

Fig. 2

Effect of Tiam1 expression in fibroblasts on EMT in SUM1315 breast cancer cells isolated from 3D co-cultures. a Quantitative RT-PCR for mRNA of indicated proteins relative to GAPDH control from SUM1315 breast cancer cells isolated from 3D spheroid co-culture with control or Tiam1-deficient mammary fibroblasts. b Quantitative RT-PCR for mRNA of indicated proteins from SUM1315 breast cancer cells isolated from 3D spheroid co-culture with control or Tiam1-overexpressing mammary fibroblasts. For A and B, results represent mean +/- SD for duplicate experiments; *Indicates p < 0.05 by t test. c Immunoblots from cell lysates of breast cancer cells derived as in A and B; biologic duplicates shown for each condition. Sn = Snail, Sl = Slug, Tw = Twist, Fn = Fibronectin, Ncad = N-cadherin, Ecad = E-cadherin

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