Skip to main content

Advertisement

Table 2 Clinico-pathological parameters of 201 human breast tumor specimens in relation to CREB3L1 gene methylation

From: Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers

  CREB3L1 methylationb
  Numbera Low High P valuec Spearman r
Parameter:
Age at diagnosis
 <68 years 100 79 21 0.018 −0.166
 ≥68 years 101 89 12   
Tumor type
 Infiltrating ductile 149 127 22 0.034 0.150
 Infiltrating colloid 21 21 0   
 Infiltrating lobular 29 18 11   
 Infiltrating papillary 1 1 0   
 Infiltrating tubular 1 1 0   
Tumor graded
 Grade 4 12 9 3 0.038 0.146
 Grade 5 50 48 2   
 Grade 6 49 41 8   
 Grade 7 23 18 5   
 Grade 8 57 44 13   
 Grade 9 10 8 2   
Estrogen receptor
 Negative 14 11 3 0.017 −0.168
 Positive 187 157 30   
Progesterone receptor
 Negative 54 42 12 0.042 −0.143
 Positive 147 126 21   
Lymph node status
 Negative 65 52 13 0.532 −0.050
 Positive 93 77 16   
 Unknown 43 39 4   
  1. aOnly patients with primary breast cancer were included. bBased on DNA sequencing results with and without sodium bisulfite treatment. cSignificance of Spearman rank correlation. Significant p values are marked in boldface. dGraded according to the Nottingham derivation of the Scarff Bloom Richardson system