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Fig. 3 | Breast Cancer Research

Fig. 3

From: Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers

Fig. 3

Immunohistochemical analyses of CREB3L1 protein expression in human breast tissue sections. Images were taken using × 10 (a, c, e, g) and × 40 (b, d, f, h, i) objective. Little or no (a, b), low (c, d), medium (e, f) and high (g, h) CREB3L1-expressing breast tumor samples. i A negative control sample where the primary antibody was omitted. j Loss of CREB3L1 protein within nuclei was associated with high-grade breast cancers (n = 19 for nuclear; n = 22 for cytoplasmic). Diamonds medians, boxes 25–75 % quartiles, vertical lines range, peak and minimum; **p <0.01

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