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Fig. 4 | Breast Cancer Research

Fig. 4

From: Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer

Fig. 4

Molecular classification of PD and spindle WAP-Cre:Ptenfl/fl:p53R270H/wt mammary tumors. a Cluster analysis of spindle and PD WAP-Cre:Ptenfl/fl:p53R270H/wt mammary tumors using an intrinsic gene signature in comparison with 13 other mouse models of breast cancer. b Cluster analysis of spindle and PDAs WAP-Cre:Ptenfl/fl:p53R270H/wt mammary tumors using an intrinsic gene signature in comparison with human tumor samples. c Cluster analysis of WAP-Cre:Ptenfl/fl:p53R270H/wt mammary tumors with human claudin-low (green) and basal-like (basal) BC using the Prat et al. claudin-low signature. BC breast cancer, PDA poorly differentiated adenocarcinoma

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