Skip to main content
Fig. 4 | Breast Cancer Research

Fig. 4

From: Breast primary epithelial cells that escape p16-dependent stasis enter a telomere-driven crisis state

Fig. 4

Chromosomal instability in breast primary epithelial cells (BPECs) correlates with telomere erosion. a The distribution of individual chromosomes involved in rearrangements correlates with the profile of individual chromosomes with telomere signal-free ends (bar diagram corresponds to 12BPEC at PD44). b Partial metaphases showing two representative examples (one in each file) of individual chromosomes with telomere signal-free ends (left row) and the involvement of these particular chromosome arms in rearrangements (M-fluorescence in situ hybridization (FISH) in the middle row and telomere + centromere FISH in the right row). c Regression between the frequencies of telomere signal-free ends among the different chromosomes and their involvement in rearrangements (diagram corresponds to 12BPEC at PD44). d Frequencies of tetraploid 12BPEC at metaphase (endo-reduplicated and non-endo-reduplicated) at the three population doublings (PDs) analyzed, with 100 metaphase plates analyzed for each donor and PD. e Representative image of a non-endo-reduplicated tetraploid BPEC at metaphase

Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us