Fig. 3

E74-like factor 5 (ELF5) expression is significantly altered in cancer. The Cancer Genome Atlas (TCGA) RNA-sequencing (RNA-seq) data for 25 cancer types (pink background) are shown, with normal tissue comparisons (green background) where available. Plotted values are for individual TCGA RNA-seq samples, and error bars represent the mean with 95 % confidence interval. TCGA cancer acronyms are used (see Table 1). a ELF5 gene expression (normalized counts) for 25 cancers with normal tissue comparisons where available. Fold changes and false discovery rates (FDRs) from Limma voom analysis are shown, with green values in bold indicating significant downregulation and red values in bold significant upregulation compared with normal (FDR < 0.05). Filt. indicates gene filtered from Limma voom analysis due to low expression. b ELF5 isoform expression in normal and cancer samples (with ELF5 gene upregulation in cancer). c ELF5 isoform expression in normal and cancer samples (with ELF5 gene downregulation in cancer). d ELF5 isoform expression in normal and cancer samples (unchanged or filtered ELF5). e ELF5 isoform expression in cancer samples without available normal samples (normal samples ≤ 2). Note smaller scale on y-axis