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Table 1 Analysis of 56 basal-like and triple-negative breast cancer tumor samples

From: SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal-like and triple-negative breast cancer

Proteins analyzed

IHC score, n

Overexpressed, n (%)

3+

2+

1+

0

SHP2

22

17

11

6

39 (70 %)

EGFR

13

20

9

5

33 (59 %)

  1. EGFR epidermal growth factor receptor, IHC immunohistochemistry, SHP2 Src homology phosphotyrosyl phosphatase 2
  2. A total of 56 basal-like and triple-negative breast cancer tumor samples were analyzed for SHP2 and EGFR by immunohistochemistry as described in Materials and methods. Samples that showed 3+ and 2+ expression levels were considered as positive for elevated expression of SHP2 and EGFR