Proteins analyzed | IHC score, n
| Overexpressed, n (%) |
---|
3+ | 2+ | 1+ | 0 |
---|
SHP2 | 22 | 17 | 11 | 6 | 39 (70Â %) |
EGFR | 13 | 20 | 9 | 5 | 33 (59Â %) |
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EGFR epidermal growth factor receptor, IHC immunohistochemistry, SHP2 Src homology phosphotyrosyl phosphatase 2
- A total of 56 basal-like and triple-negative breast cancer tumor samples were analyzed for SHP2 and EGFR by immunohistochemistry as described in Materials and methods. Samples that showed 3+ and 2+ expression levels were considered as positive for elevated expression of SHP2 and EGFR