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Fig. 1 | Breast Cancer Research

Fig. 1

From: SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal-like and triple-negative breast cancer

Fig. 1

In vivo tumorigenesis studies. a Analysis of Src homology phosphotyrosyl phosphatase 2 (SHP2) expression in parental (P), control (C), shRNA-1 (sh-1), and shRNA-2 (sh-2) cells derived from MDA-MB-231 and MDA-MB-468 cells. b Tumor growth rate initiated by transplantation of control (Con) and SHP2-silenced (sh-2) cells derived from the MDA-MB-231 cell line. Data shown are mean ± standard error of the mean of tumor volume collected over a period of 9 weeks from six mice in each group. c Effect of SHP2 silencing on survival of mice that received transplanted Con and sh-2 cells. d Hematoxylin and eosin (H & E)–stained mammary gland tumor sections harvested from mice that received transplanted control and sh-2 MDA-MB-231 cells. e H & E staining of lung and liver sections harvested from mice that received transplanted control and sh-2 MDA-MB-231 cells

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