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Fig. 4 | Breast Cancer Research

Fig. 4

From: HDAC6 activity is a non-oncogene addiction hub for inflammatory breast cancers

Fig. 4

Histone deacetylase 6 (HDAC6) activity is higher in primary inflammatory breast cancer (IBC) than in non-IBC. a Identification of the regulon controlled by HDAC6. The table shows the GO terms associated with the 162 transcripts of the HDAC6 regulon in breast cancer. b Venn diagrams showing the overlap between the HDAC6 regulons obtained from the analysis of the breast cancer (BRCA), colorectal cancer (COAD-READ) and lung adenocarcinoma (LUAD) data sets from The Cancer Genome Atlas (TCGA). c HDAC6 activity score inferred by expression of HDAC6 regulon genes upon treatment with Ricolinostat for 0, 3, 6 and 12 hours (left). Expression change of the HDAC6 regulon network over time upon Ricolinostat treatment at 0 and 12 hours (right): node is color-coded by z-score-transformed expression with red indicating high and blue low expression, and node size is also proportional to the corresponding expression. Edge is coded by the Pearson correlation of HDAC6 and corresponding regulon node with red indicating positive and blue negative, and the width is proportional to the absolute correlation value. d mRNA expression levels (left) and the HDAC6-score (right) in primary IBC and non-IBC clinical samples. ARACNe reconstruction of gene regulatory networks

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