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Fig. 3 | Breast Cancer Research

Fig. 3

From: β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion

Fig. 3

β2AR signaling decreases focal adhesions and decreases migration on two-dimensional surfaces. a Representative confocal sections of tumor cells stained for actin and paxillin to identify focal adhesions. Scale bar: 10 μm. Square brackets in inset identify focal adhesions. b The effect of isoproterenol on focal adhesion length and number of adhesions per cell was quantified. c The effect of isoproterenol on cell migration on two-dimensional fibronectin surfaces over time was quantified. d Representative time series images of cells treated with vehicle or isoproterenol. Red cross marks the location of the cell at the commencement of treatment. Time in hours is indicated. N > 20 cells per condition. Error bars: SEM. *p <0.05, **p <0.01 and ***p <0.001

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