Skip to main content

Table 4 Breast cancer incidence cross-classified by 10-year risk groups from the Tyrer-Cuzick and Gail models when combined with breast density

From: Mammographic density adds accuracy to both the Tyrer-Cuzick and Gail breast cancer risk models in a prospective UK screening cohort

  Risk model combined with density (10-year risk)
Risk model <1 % 1–2 % 2–3.5 % 3.5–5 % 5–8 % >8 % Total
Tyrer-Cuzick
<1 % 0/60 (0.0 %) 0/18 (0.0 %)      0/78 (0.0 %)
1–2 % 4/700 (0.6 %) 60/6910 (0.9 %) 18/1976 (0.9 %) 2/85 (2.4 %) 0/8 (0.0 %)   84/9679 (0.9 %)
2–3.5 % 0/6 (0.0 %) 69/7425 (0.9 %) 221/16,515 (1.3 %) 75/3807 (2.0 %) 16/652 (2.5 %) 1/24 (4.2 %) 382/28,429 (1.3 %)
3.5–5 %   0/29 (0.0 %) 21/2689 (0.8 %) 66/3139 (2.1 %) 35/1508 (2.3 %) 2/139 (1.4 %) 124/7504 (1.7 %)
5–8 %    3/144 (2.1 %) 20/1181 (1.7 %) 48/2257 (2.1 %) 16/758 (2.1 %) 87/4340 (2.0 %)
>8 %     0/2 (0.0 %) 5/172 (2.9 %) 15/424 (3.5 %) 20/598 (3.3 %)
Total 4/766 (0.5 %) 129/14,382 (0.9 %) 263/21324 (1.2 %) 163/8214 (2.0 %) 104/4597 (2.3 %) 34/1345 (2.5 %) 697/50,628 (1.4 %)
Gail
<1 %        
1–2 % 0/17 (0.0 %) 5/601 (0.8 %) 5/257 (1.9 %) 0/14 (0.0 %)    10/889 (1.1 %)
2–3.5 % 0/1 (0.0 %) 33/4286 (0.8 %) 170/14,115 (1.2 %) 62/3894 (1.6 %) 15/756 (2.0 %) 0/42 (0.0 %) 280/23,094 (1.2 %)
3.5–5 %   1/90 (1.1 %) 68/7048 (1.0 %) 118/7751 (1.5 %) 75/3533 (2.1 %) 11/315 (3.5 %) 273/18,737 (1.5 %)
5–8 %    3/277 (1.1 %) 21/1851 (1.1 %) 63/3610 (1.7 %) 20/1105 (1.8 %) 107/6843 (1.6 %)
>8 %     0/15 (0.0 %) 8/316 (2.5 %) 19/734 (2.6 %) 27/1065 (2.5 %)
Total 0/18 (0.0 %) 39/4977 (0.8 %) 246/21,697 (1.1 %) 201/13,525 (1.5 %) 161/8215 (2.0 %) 50/2196 (2.3 %) 697/50,628 (1.4 %)
  1. Bold cells indicate combinations that increased risk when density was added