Fig. 3
Fully regressed Wnt1/iR1 tumors after BGJ398 treatment recur slowly following cessation of treatment. a Scheme for BGJ398 treatment and tumor recurrence (first recurrence, n = 16). b Timing of tumor regression and recurrence for individual Wnt1/iR1 tumors. BGJ398 treatment was started on day 0, and stopped on day 10. c Scheme for BGJ398 treatment and tumor recurrence (second recurrence, n = 7). d Timing of tumor regression, first and second recurrence for individual Wnt1/iR1 tumors. e Comparison of the recurrent latency between the first and the second recurrence. Latency is calculated from the day of BGJ398 withdrawal to the day when the recurrent tumor reached 100 mm3; p < 0.05. f Immunofluorescence double staining of K5 (red) and K8 (green) in primary tumors and recurrent tumors. Nuclear staining is shown in blue (4′, 6-diamidino-2-phenylindole (DAPI)) in all panels