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Fig. 1 | Breast Cancer Research

Fig. 1

From: Upregulation of EGFR signaling is correlated with tumor stroma remodeling and tumor recurrence in FGFR1-driven breast cancer

Fig. 1

Human breast tumors with both FGFR1 amplification/overexpression and active WNT signaling exhibited the worst prognosis. a Kaplan-Meier curves show the disease-specific survival of patients in METABRIC dataset stratified by the statuses of WNT signature. WNT status is determined by ranking the continuous WNT score (sum of upregulated genes – sum of downregulated genes), and then separating all patients into three equal tertiles. b. The Kaplan-Meier curves show the disease-specific survival of patients in METABRIC dataset stratified by the status of FGFR1 amplification/overexpression. c. Kaplan-Meier curves show the disease-specific survival of patients in METABRIC dataset stratified by the status of FGFR1 amplification/overexpression and WNT signature. The number of events and total patients in each subset is indicated in parentheses. The p values are calculated based on log rank tests. FGFR1 Fibroblast growth factor receptor 1

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Breast Cancer Research

ISSN: 1465-542X

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