Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet

Breast Cancer Research

Table 3 Gene expression in switched diet DMBA-induced tumors

		Fold regulation (compared with LFD-HFD)
Symbol	Description	HFD-LFD-early	HFD-LFD-late
Ntf3	Neurotrophin 3	70.0	NS
Trp53	Transformation related protein 53	1.5	−1.2
Ccnd2	Cyclin D2	12.4	3.1
Ctnnb1	Catenin (cadherin associated protein), beta 1	5.4	1.4
Brca1	Breast cancer 1	2.9	1.4
Apaf1	Apoptotic peptidase activating factor 1	1.4	NS
Bmp7	Bone morphogenetic protein 7	5.6	NS
Bmp10	Bone morphogenetic protein 10	−2.7	NS

DMBA 7,12-dimethylbenz[a]anthracene HFD high saturated animal fat diet, HFD-LFD, mice on high saturated animal fat diet switched to low-fat diet, LFD low-fat diet, LFD-HFD mice on low-fat diet switched to high saturated animal fat diet
p < 0.05 for all genes listed, except NS = no significant change [n = 4 tumors per diet group (LFD-HFD, HFD-LFD-early, HFD-LFD-late)]

ISSN: 1465-542X