Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet

Breast Cancer Research

Table 1 Tumor characteristics

Diet	Weeks after first DMBA treatment	Histopathology	Hormone receptor status^a
LFD-HFD	23	Glandular/spindle cell carcinoma	ER−PR−
	28	Papillary carcinoma	ER−PR−
	31	Glandular carcinoma	ER+PR+
	37	Glandular carcinoma	ER+PR+
	38	Papillary carcinoma	ER+PR+
	42	Glandular carcinoma	ER+PR+
HFD-LFD-early	10	Adenosquamous carcinoma	ER−PR−
	10	Adenosquamous carcinoma	ER−PR−
	16	Adenosquamous carcinoma	ER−PR−
	14	Adenosquamous carcinoma	ER−PR−
	17	Adenosquamous carcinoma	ER−PR−
	19	Cribriform carcinoma	ER−PR−
HFD-LFD-late	26	Papillary carcinoma	ER−PR−
	28	Papillary carcinoma	ER+PR+
	33	Glandular carcinoma	ER+PR+
	35	Glandular carcinoma	ER+PR+
	38	Adenosquamous carcinoma	ER−PR−

DMBA 7,12-dimethylbenz[a]anthracene, ER estrogen receptor, HFD high saturated animal fat diet, LFD low-fat diet, PR progesterone receptor
^aER status was based on >10 % receptor-positive cell. All ER−PR− tumors that were tested were also Her2−

ISSN: 1465-542X