Fig. 4
From: Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet
Microarray heat map cluster analysis. The heat map and dendrogram represent a two-class significance analysis of genes differentially expressed between early vs. late tumor onset and high saturated animal fat diet (HFD) vs. a low-fat diet (LFD). Two gene clusters were identified: one enriched for genes upregulated among early-occurring tumors (gray bar) and one enriched for genes downregulated among early-occurring tumors (black bar). Early-occurring tumors from HFD- and HFD-LFD-fed mice cluster together. Diet group, early vs. late tumor onset, and adenosquamous vs. other histologies are noted. HFD-LFD mice on high saturated animal fat diet switched to low-fat diet, LFD-HFD mice on low-fat diet switched to high saturated animal fat diet