Fig. 3
From: Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet
Overall tumor characteristics in HFD-, LFD-, HFD-LFD-, and LFD-HFD-fed mice. a Blood vessel density (CD31 staining) was increased in LFD-HFD-fed murine mammary tumors (#p = 0.07) and significantly increased in HFD- and HFD-LFD-fed murine mammary tumors compared with LFD-fed murine mammary tumors. *p < 0.05. b Macrophage (Macs; F4/80 staining) recruitment was increased within the stroma of tumors from mice fed a HFD-LFD vs. LFD-HFD. *p < 0.05. Bars represent mean ± standard error of the mean; n = 4–10 tumors per diet treatment. Arg1 arginase 1, HFD high saturated animal fat diet, HFD-LFD mice on high saturated animal fat diet switched to low-fat diet, LFD low-fat diet, LFD-HFD mice on low-fat diet switched to high saturated animal fat diet