TY - JOUR AU - Aupperlee, Mark D. AU - Zhao, Yong AU - Tan, Ying Siow AU - Zhu, Yirong AU - Langohr, Ingeborg M. AU - Kirk, Erin L. AU - Pirone, Jason R. AU - Troester, Melissa A. AU - Schwartz, Richard C. AU - Haslam, Sandra Z. PY - 2015 DA - 2015/11/02 TI - Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet JO - Breast Cancer Research SP - 138 VL - 17 IS - 1 AB - Increased animal fat consumption is associated with increased premenopausal breast cancer risk in normal weight, but not overweight, women. This agrees with our previous findings in obesity-resistant BALB/c mice, in which exposure to a high saturated animal fat diet (HFD) from peripuberty through adulthood promoted mammary tumorigenesis. Epidemiologic and animal studies support the importance of puberty as a life stage when diet and environmental exposures affect adult breast cancer risk. In this study, we identified the effects of peripubertal exposure to HFD and investigated its mechanism of enhancing tumorigenesis. SN - 1465-542X UR - https://doi.org/10.1186/s13058-015-0646-4 DO - 10.1186/s13058-015-0646-4 ID - Aupperlee2015 ER -