Skip to main content

Table 3 Association of KEGG pathways with clinical variables

From: Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response

A. Pathological complete remission (pCR)
Pathway Genes in pathway Genes mutated pCR (number) No pCR (number) pCR and mutated (number) No pCR and mutated (number) P value Adjusted p value
 Calcium signaling pathway 177 6 25 31 0 6 0.03 0.41
 Notch signaling pathway 47 4 25 31 4 0 0.03 0.41
 TGF-beta signaling pathway 85 6 25 31 0 5 0.06 0.41
 Phosphatidylinositol signaling system 78 11 25 31 4 12 0.08 0.41
 Focal adhesion 200 25 25 31 7 16 0.10 0.41
B. BRCA proficiency
Pathway Genes in pathway Genes mutated BRCA mutated/methylated (number) BRCA proficient (number) BRCA mutated/methylated, and mutated (number) BRCA proficient and mutated (number) P value Adjusted p value
 Wnt signaling pathway 151 12 29 27 21 12 0.06 0.78
 Jak-STAT signaling pathway 155 3 29 27 2 6 0.14 0.78
 Regulation of actin cytoskeleton 214 16 29 27 6 11 0.15 0.78
 MAPK signaling pathway 268 28 29 27 21 14 0.17 0.78
 mTOR signaling pathway 52 5 29 27 3 7 0.17 0.78
  1. TGF transforming growth factor, MAPK mitogen activated protein kinase, mTOR mammalian target of rapamycin