Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response

Breast Cancer Research

Table 2 Association of mutations with BRCA proficiency

Gene	BRCA mutated/methylated (number)	BRCA proficient (number)	BRCA mutated/methylated, and mutated (number)^a	BRCA proficient and mutated (number)^a	P value	Adjusted p value
PIK3CA	29	27	0	5	0.02	0.11
TP53	29	27	18	12	0.28	0.59
TTN ^b	29	27	4	1	0.35	0.59
ALMS1	29	27	1	2	0.60	0.76
HSP90AB1	29	27	2	1	1.00	1.00

^aAll samples with a BRCA mutation/methylation and a mutation in the respective gene, and applies likewise to the BRCA proficient and mutated column, Table 3, and Table 4. ^bThe TTN gene is often mutated due to its greater length and may not be cancer-related (see also Additional file 4: Table S3)

ISSN: 1465-542X