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Table 2 Association of mutations with BRCA proficiency

From: Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response

Gene BRCA mutated/methylated (number) BRCA proficient (number) BRCA mutated/methylated, and mutated (number)a BRCA proficient and mutated (number)a P value Adjusted p value
PIK3CA 29 27 0 5 0.02 0.11
TP53 29 27 18 12 0.28 0.59
TTN b 29 27 4 1 0.35 0.59
ALMS1 29 27 1 2 0.60 0.76
HSP90AB1 29 27 2 1 1.00 1.00
  1. aAll samples with a BRCA mutation/methylation and a mutation in the respective gene, and applies likewise to the BRCA proficient and mutated column, TableĀ 3, and TableĀ 4. bThe TTN gene is often mutated due to its greater length and may not be cancer-related (see also Additional file 4: Table S3)