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Table 1 Patient and tumor characteristics

From: Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response

Characteristic

Values (n = 56 patients)

Age

 

 Median, range

40 (23–74)

Tumor stage

 

 1

5 (9)

 2

40 (71)

 3

7 (13)

 4

4 (7)

Nodal stage

 

 Lymph nodes negative

19 (34)

 Lymph nodes positive

37 (66)

Grade

 

 II

18 (32)

 III

34 (61)

 Not determined

4 (7)

Chemotherapy

 

 6 × dose dense doxorubicin/cyclophosphamide

43 (77)

 3 × dose dense doxorubicin/cyclophosphamide, 3 × docetaxel/capecitabine

5 (9)

 4 × dose dense doxorubicin/cyclophosphamide, 2 × cyclophosphamide/thiotepa/carboplatin

8 (14)

BRCA germline mutation status (Sanger sequencing)

 

BRCA1 mutation

10 (18)

BRCA2 mutation

2 (4)

 Wildtype

39 (70)

 Not determined

5 (9)

BRCA1 promoter methylation

 

 No BRCA1 methylation

39 (70)

BRCA1 methylation

17 (30)

Response breast and lymph nodes

 

 No pathological complete remission

31 (55)

 Pathological complete remission

25 (45)

Relapse

 

 No relapse

47 (84)

 Relapse

9 (16)

  1. Values are n (%) unless stated otherwise