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Table 1 Description and summary of tumor histologies

From: Transformation of enriched mammary cell populations with polyomavirus middle T antigen influences tumor subtype and metastatic potential

Tumor histology Overall cellular organization Histology description Cytokeratin staining
Acinar Well differentiated Acini with bilayered, duct-like epithelial cells Maintenance of ductal morphology with K8 cells surrounding clear lumens and K14 cells adjacent to the stroma
Papillary Well differentiated Epithelial cell sheets, generally 2–3 layers thick, surrounded by stroma Maintenance of luminal and basal cell organization with K14-positive cells adjacent to the stroma
Solid adenocarcinoma Poorly differentiated Multilayered epithelial cells grouped in large units (>100 μm in diameter) surrounded by 1–2 layers of stromal cells Primarily K8-positive with sparse K14-positive cells near stromal regions
Squamous Poorly differentiated Adenocarcinoma with clusters of keratin pearls and sheets of squamous epithelia Large solid areas of either K8- or K14-positive cells; K14 cells are localized near keratinized regions
Lipid-rich Poorly differentiated Heavily vacuolated epithelial cells Primarily K8-positive
Sebaceous-like Poorly differentiated Epithelial cells with enlarged nuclei and foamy cytoplasms Primarily K14-positive
  1. Abbreviations: K8 keratin 8, K14 keratin 14
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Breast Cancer Research

ISSN: 1465-542X

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