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Table 3 Effect of body mass index (BMI) group (reference group underweight/normal weight) on overall survival (OS) and disease-free survival (DFS) according to molecular subtype in fully adjusted multivariate Cox regressions

From: The influence of obesity on survival in early, high-risk breast cancer: results from the randomized SUCCESS A trial

Molecular subtype Outcome parameter   Hazard ratio 95 % CI p value
Luminal A like OS BMI group    0.530
  Overweight vs. underweight/normal weight 0.86 0.48–1.52 0.594
  Slightly obese vs. underweight/normal weight 1.32 0.71–2.47 0.384
  Moderately obese vs. underweight/normal weight 1.72 0.69–4.30 0.247
  Severely obese vs. underweight/normal weight 1.51 0.20–11.42 0.688
DFS BMI group    0.851
  Overweight vs. underweight/normal weight 1.21 0.81–1.82 0.359
  Slightly obese vs. underweight/normal weight 1.10 0.66–1.83 0.714
  Moderately obese vs. underweight/normal weight 1.42 0.65–3.09 0.382
  Severely obese vs. underweight/normal weight 0.82 0.11–6.06 0.849
Luminal B like OS BMI group    0.384
  Overweight vs. underweight/normal weight 0.87 0.44–1.75 0.701
  Slightly obese vs. underweight/normal weight 1.29 0.55–3.00 0.561
  Moderately obese vs. underweight/normal weight 0.58 0.17–2.07 0.405
  Severely obese vs. underweight/normal weight 2.84 0.71–11.40 0.141
DFS BMI group    0.156
  Overweight vs. underweight/normal weight 1.18 0.72–1.93 0.513
  Slightly obese vs. underweight/normal weight 1.46 0.78–2.74 0.235
  Moderately obese vs. underweight/normal weight 0.76 0.29–2.00 0.584
  Severely obese vs. underweight/normal weight 3.32 1.17–9.46 0.024
HER2 positive OS BMI group    0.425
  Overweight vs. underweight/normal weight 0.86 0.46–1.62 0.646
  Slightly obese vs. underweight/normal weight 0.82 0.37–1.80 0.612
  Moderately obese vs. underweight/normal weight 1.36 0.43–4.35 0.601
  Severely obese vs. underweight/normal weight 2.78 0.75–10.34 0.128
DFS BMI group    0.198
  Overweight vs. underweight/normal weight 1.08 0.68–1.69 0.754
  Slightly obese vs. underweight/normal weight 0.81 0.44–1.50 0.503
  Moderately obese vs. underweight/normal weight 1.09 0.43–2.79 0.858
  Severely obese vs. underweight/normal weight 3.28 1.14–9.48 0.028
Triple negative OS BMI group    0.015
  Overweight vs. underweight/normal weight 1.41 0.88–2.25 0.155
  Slightly obese vs. underweight/normal weight 1.27 0.67–2.41 0.458
  Moderately obese vs. underweight/normal weight 0.51 0.12–2.21 0.368
  Severely obese vs. underweight/normal weight 3.85 1.69–8.77 0.001
DFS BMI group    0.011
  Overweight vs. underweight/normal weight 1.34 0.91–1.97 0.140
  Slightly obese vs. underweight/normal weight 1.29 0.77–2.17 0.335
  Moderately obese vs. underweight/normal weight 0.36 0.09–1.48 0.154
  Severely obese vs. underweight/normal weight 3.02 1.50–6.08 0.002
  1. CI confidence interval, HER2 human epidermal growth factor receptor 2
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Breast Cancer Research

ISSN: 1465-542X

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