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Table 3 Effect of body mass index (BMI) group (reference group underweight/normal weight) on overall survival (OS) and disease-free survival (DFS) according to molecular subtype in fully adjusted multivariate Cox regressions

From: The influence of obesity on survival in early, high-risk breast cancer: results from the randomized SUCCESS A trial

Molecular subtype

Outcome parameter

 

Hazard ratio

95 % CI

p value

Luminal A like

OS

BMI group

  

0.530

  Overweight vs. underweight/normal weight

0.86

0.48–1.52

0.594

  Slightly obese vs. underweight/normal weight

1.32

0.71–2.47

0.384

  Moderately obese vs. underweight/normal weight

1.72

0.69–4.30

0.247

  Severely obese vs. underweight/normal weight

1.51

0.20–11.42

0.688

DFS

BMI group

  

0.851

  Overweight vs. underweight/normal weight

1.21

0.81–1.82

0.359

  Slightly obese vs. underweight/normal weight

1.10

0.66–1.83

0.714

  Moderately obese vs. underweight/normal weight

1.42

0.65–3.09

0.382

  Severely obese vs. underweight/normal weight

0.82

0.11–6.06

0.849

Luminal B like

OS

BMI group

  

0.384

  Overweight vs. underweight/normal weight

0.87

0.44–1.75

0.701

  Slightly obese vs. underweight/normal weight

1.29

0.55–3.00

0.561

  Moderately obese vs. underweight/normal weight

0.58

0.17–2.07

0.405

  Severely obese vs. underweight/normal weight

2.84

0.71–11.40

0.141

DFS

BMI group

  

0.156

  Overweight vs. underweight/normal weight

1.18

0.72–1.93

0.513

  Slightly obese vs. underweight/normal weight

1.46

0.78–2.74

0.235

  Moderately obese vs. underweight/normal weight

0.76

0.29–2.00

0.584

  Severely obese vs. underweight/normal weight

3.32

1.17–9.46

0.024

HER2 positive

OS

BMI group

  

0.425

  Overweight vs. underweight/normal weight

0.86

0.46–1.62

0.646

  Slightly obese vs. underweight/normal weight

0.82

0.37–1.80

0.612

  Moderately obese vs. underweight/normal weight

1.36

0.43–4.35

0.601

  Severely obese vs. underweight/normal weight

2.78

0.75–10.34

0.128

DFS

BMI group

  

0.198

  Overweight vs. underweight/normal weight

1.08

0.68–1.69

0.754

  Slightly obese vs. underweight/normal weight

0.81

0.44–1.50

0.503

  Moderately obese vs. underweight/normal weight

1.09

0.43–2.79

0.858

  Severely obese vs. underweight/normal weight

3.28

1.14–9.48

0.028

Triple negative

OS

BMI group

  

0.015

  Overweight vs. underweight/normal weight

1.41

0.88–2.25

0.155

  Slightly obese vs. underweight/normal weight

1.27

0.67–2.41

0.458

  Moderately obese vs. underweight/normal weight

0.51

0.12–2.21

0.368

  Severely obese vs. underweight/normal weight

3.85

1.69–8.77

0.001

DFS

BMI group

  

0.011

  Overweight vs. underweight/normal weight

1.34

0.91–1.97

0.140

  Slightly obese vs. underweight/normal weight

1.29

0.77–2.17

0.335

  Moderately obese vs. underweight/normal weight

0.36

0.09–1.48

0.154

  Severely obese vs. underweight/normal weight

3.02

1.50–6.08

0.002

  1. CI confidence interval, HER2 human epidermal growth factor receptor 2
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Breast Cancer Research

ISSN: 1465-542X

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