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Table 1 SHAPE-2 study inclusion and exclusion criteria

From: Effect of weight loss, with or without exercise, on body composition and sex hormones in postmenopausal women: the SHAPE-2 trial

Inclusion criteria Exclusion criteria
Female Presently using sex hormones
Age 50–69 yr Use of β-blockers or oral corticosteroids
Postmenopausal (>12 mo since last menses) Smoking
Body mass index (BMI) 25–35 kg/m2 Alcohol or drug abuse
Insufficiently active (<2 h/wk of at least moderately intensive activities (≥4 MET)) Diagnosed breast cancer (present or history)
Willing to be randomly assigned to one of the three study arms Diagnosed with other cancer (present or <5 yr of history), except non-melanoma skin cancer
Informed consent for all screening and study activities Diabetes mellitus or other (unstable) endocrine-related diseases
  Any disorder that might impede participation in the exercise programme
  Following, or intention to follow, a structured weight loss programme elsewhere
  Investigator’s opinion (i.e., successful fulfilling of the programme highly unlikely)
  1. Source: van Gemert et al. [11]
  2. Abbreviations: MET metabolic equivalents, SHAPE Sex Hormones and Physical Exercise study