Table 1 SHAPE-2 study inclusion and exclusion criteria

Female

Presently using sex hormones

Age 50–69 yr

Use of β-blockers or oral corticosteroids

Postmenopausal (>12 mo since last menses)

Smoking

Body mass index (BMI) 25–35 kg/m²

Alcohol or drug abuse

Insufficiently active (<2 h/wk of at least moderately intensive activities (≥4 MET))

Diagnosed breast cancer (present or history)

Willing to be randomly assigned to one of the three study arms

Diagnosed with other cancer (present or <5 yr of history), except non-melanoma skin cancer

Informed consent for all screening and study activities

Diabetes mellitus or other (unstable) endocrine-related diseases

Any disorder that might impede participation in the exercise programme

Following, or intention to follow, a structured weight loss programme elsewhere

Investigator’s opinion (i.e., successful fulfilling of the programme highly unlikely)